患有2型糖尿病的老年男性骨微架构损伤的危险因素-MrOS研究
Malak Faraj1, Ann V Schwartz2, Andrew J Burghardt3
1Research Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
The Journal of clinical endocrinology and metabolism
|July 12, 2024
概括
患有2型糖尿病 (T2DM) 的老年男性有较小的骨大小,增加骨脆弱的风险. 糖尿病持续时间较长和胰岛素使用进一步影响骨结构和强度.
科学领域:
- 内分泌学 在内分泌学.
- 骨生物学 骨生物学 骨生物学
- 老年病的医生 老年病的医生
背景情况:
- 损坏的骨微型架构可能会导致2型糖尿病 (T2DM) 的骨脆弱.
- 关于T2DM对男性骨结构的影响的数据有限.
- 高分辨率的外围定量计算断层扫描 (HR-pQCT) 评估了骨的微观结构.
研究的目的:
- 调查老年男性T2DM和HR-pQCT参数之间的关联.
- 探索糖尿病持续时间和胰岛素使用如何影响T2DM中的骨参数.
- 确定特定的骨参数是否与T2DM男性骨折风险有关.
主要方法:
- 在1777名来自男性骨质疏松性骨折研究的老年男性中分析的HR-pQCT扫描.
- 通过自我报告或药物使用来确定T2DM状态.
- 以共变量调整的线性回归模型比较了T2DM和非T2DM组之间的HR-pQCT参数.
主要成果:
- 患有T2DM的男性在骨的横截面和皮质区域总体较小.
- 在T2DM和非T2DM组之间,状体指数和皮层孔隙性是相似的.
- 较长的糖尿病持续时间 (≥10年) 与较高的皮质多孔性和椎厚度相关;胰岛素使用与皮质面积/厚度减少和较低的故障负载相关.
结论:
- 患有T2DM的老年男性骨大小减少,可能导致骨脆弱.
- 糖尿病持续时间较长与皮层孔隙性增加有关.
- 在T2DM男性中使用胰岛素与较差的骨结构和骨强度降低有关,增加骨折风险.
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