草甘暴露对肠道微生物群,新陈代谢和微观结构的影响:系统性审查
Amanda da Cunha Ignácio1, Andressa Maria Dos Reis Guerra1, Thaiany Goulart de Souza-Silva2
1Faculty of Medicine, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil.
Food & function
|July 12, 2024
概括
草甘除草剂通过改变肠道微生物群和微观结构来破坏肠道健康,可能导致诸如克罗恩病和阿尔茨海默病等疾病.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 草甘是全球广泛使用的除草剂,引发了对其对非标生物的影响的担忧.
- 世界卫生组织在2015年将草甘归类为潜在致癌物,加剧了关于其安全性的辩论.
- 了解草甘对肠道健康的影响对于公共卫生和环境安全至关重要.
研究的目的:
- 系统地审查草甘及其配方对肠道微生物群,微观结构和动物新陈代谢的影响.
- 综合关于草甘如何影响肠道健康和相关代谢过程的发现.
- 评估草甘暴露与肠道和全身疾病的发展之间的潜在联系.
主要方法:
- 按照PRISMA指南进行系统审查.
- 在PubMed/Medline,Scopus和Web of Science数据库中进行的搜索.
- 使用SYRCLE策略评估的偏差风险.
主要成果:
- 草甘配方诱导肠道失生症,改变细菌代谢,肠道透性和粘液分泌.
- 观察到肠道微小和光膜的损伤,以及免疫学,酶学和遗传学变化.
- 代谢障碍包括对脂质,能量,辅因子和维生素代谢的影响,以及复制,修复和翻译过程.
结论:
- 基于草甘的除草剂会导致肠道发生显著的变化,包括失活症和微观结构损伤.
- 这些变化可能导致代谢功能障碍,并与肠道和全身疾病的风险增加有关.
- 需要进一步的研究,以充分阐明草甘暴露的长期健康后果.
更多相关视频
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
9.6K
08:33Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
13.0K
相关概念视频
Bacterial Flora of the Large Intestine
416
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
416
Anatomy of the Intestines
71.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.7K
What is Monogastric Digestion?
71.0K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.0K
Irritable Bowel Syndrome I: Introduction
265
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
265
