流感疫苗接种与SARS-CoV-2感染之间的关联
Marwan Ma'ayeh1, Jessica A de Voest2, Brenna L Hughes3
1Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.
概括
流感疫苗接种并没有降低孕妇的COVID-19严重程度或SARS-CoV-2感染风险. 这项研究发现,流感疫苗和COVID-19的孕妇的更好的结果之间没有显著的关联.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 新出现的数据表明,流感疫苗接种可以保护非怀孕的个人免受SARS-CoV-2感染和严重性.
- 流感疫苗接种对孕妇COVID-19结果的影响尚不清楚.
研究的目的:
- 为了确定流感疫苗接种是否与孕妇的COVID-19严重程度有关.
- 评估感染SARS-CoV-2的孕妇中流感疫苗接种与孕妇/新生儿结局之间的关联.
- 检查流感疫苗接种与怀孕期间感染SARS-CoV-2的风险之间的联系.
主要方法:
- 怀孕个体检测SARS-CoV-2阳性后期队列分析 (2020年3月至8月).
- 对一组随机分娩的分析,以评估SARS-CoV-2感染风险.
- 通过单变量和多变量分析,检查了2019年流感疫苗接种与COVID-19严重程度,孕产妇/孕产后结果和SARS-CoV-2感染之间的关联.
主要成果:
- 在2325名感染SARS-CoV-2的孕妇中,45.9%接种了2019年流感疫苗. 在流感疫苗接种和中度至危急的COVID-19 (aOR 1.10,95%CI 0.90-1.34) 之间没有发现任何关联.
- 流感疫苗接种与不良的孕产妇或围产期结局无关.
- 在8152例分娩队列中,先前的流感疫苗接种与SARS-CoV-2感染的可能性不同无关 (aOR为0.94,95%CI为0.74-1.19).
结论:
- 之前的流感疫苗接种在孕妇中没有显示出对COVID-19严重程度的保护作用.
- 流感疫苗接种与孕妇感染SARS-CoV-2的几率降低无关.
- 研究结果表明,接种流感疫苗不会改变COVID-19的临床过程或怀孕期间感染风险.
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