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尽管在双重单亲遗传的双动物中,男性线粒体DNA的选择放松,但线粒体兼容性仍然保持着
Chase H Smith1, Raquel Mejia-Trujillo1, Justin C Havird1
1Department of Integrative Biology, University of Texas at Austin, Austin, TX, United States.
Evolution; international journal of organic evolution
|July 12, 2024
概括
在双重单亲遗传 (DUI) 的双动物中,雌性和雄性线粒体DNA (mtDNA) 都与核基因共同演变. 这确保了兼容性,即使男性mtDNA经历了放松的选择.
科学领域:
- 进化生物学 进化生物学
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 分子核共同进化,即线粒体和核基因组之间的相互作用,在真核生物中普遍存在.
- 在双动物中,双重单亲遗传 (DUI) 呈现了一个独特的系统,其中雌性传递mtDNA (F mtDNA),雄性传递独特的mtDNA (M mtDNA) 专门给儿子.
- 与F mtDNA基因相比,M mtDNA基因主要在精子中起作用,可能在放松的选择下演变.
研究的目的:
- 为了研究双DUI系统中的线粒核相互作用和共同进化动态.
- 为了确定核编码氧化酸化 (OXPHOS) 蛋白是否与F和M mtDNA保持兼容性.
- 探索塑造M mtDNA的进化压力及其与核基因组的相互作用.
主要方法:
- 比较遗传学来分析进化关系.
- 转录学用于评估基因表达水平.
- 蛋白质组学研究蛋白质相互作用和丰富性.
- 与OXPHOS基因相关的线核兼容性的分析.
主要成果:
- 核OXPHOS蛋白质表现出保守的共同进化,并与F和M mtDNA保持兼容性.
- 线粒体重组不会影响线粒体核兼容性.
- 在具有M mtDNA的组织中没有观察到核编码的OXPHOS基因的升级,以弥补潜在的功能障碍.
- 选择在M mtDNA上保持了轻松的选择,尽管选择在M mtDNA上积极保持了线粒核兼容性.
结论:
- 分子核共进化和兼容性是通过选择在双DUI系统中保持的强大特征.
- 诸如严格的精子传播,减少有效种群规模和更高的突变率等因素可能会影响M mtDNA进化.
- 这些发现表明,线核共同进化的兼容性是真核生物之间广泛的现象.
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