在培养基阳性创伤性开口骨折中预防性抗生素覆盖率的评估
Rachel LaBianca Toler1, Susan E Hamblin2, Lauren E Mangan3
1Duke Regional Hospital, Durham, North Carolina.
Journal of surgical orthopaedic advances
|July 12, 2024
概括
开口骨折的预防性抗生素部分覆盖了病原体,超过一半的患者获得了适当的覆盖. 然而,没有初始抗生素治疗的患者的阳性培养速度更快.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 预防性抗微生物治疗开口骨折的指导方针各不相同.
- 评估机构抗生素方案的有效性至关重要.
研究的目的:
- 评估机构预防性抗生素协议对开放骨折中的病原体的覆盖范围.
- 为了比较有或没有足够的抗生素覆盖范围的患者之间的结果.
主要方法:
- 成年创伤患者的回顾性队列研究,这些患者有开放骨折和阳性培养.
- 分析了75名患者,比较了那些被预防性抗生素覆盖的人与那些没有被覆盖的人.
主要成果:
- 其中53%的患者接受了预防性抗生素治疗.
- 在两组中,多药耐药性病原体是常见的 (58%的覆盖率与74%的不覆盖率相比).
- 没有初始抗生素治疗的患者的阳性培养时间中位数显著缩短 (30.2天 vs 102.1天).
结论:
- 机构预防性抗生素协议在覆盖开放骨折病原体方面表现出部分有效性.
- 进一步优化抗生素策略是有必要的,以改善患者的治疗结果和减少感染风险.
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