血清卡尔格兰林C作为在炎症性肠道疾病中活动的非侵入性预测剂
Hany S Rasmy1, Noha A Elnakeeb1, Mohamed F Mohamed1
1Department of Internal Medicine, Hepatology and Gastroenterology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
The Egyptian journal of immunology
|July 12, 2024
概括
血清卡尔格兰林C显示为炎症性肠病 (IBD) 的非侵入性生物标志物具有前途. 它可以帮助预测疾病活动和严重程度,帮助IBD患者的诊断和缓解监测.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 炎症性肠病 (IBD) 呈现慢性,复发性症状,影响生活质量和医疗保健成本.
- 目前IBD的诊断方法可能具有侵入性,因此需要寻找非侵入性生物标志物.
- 卡尔格拉努林C是一种促炎性结合蛋白,是IBD评估的潜在候选者.
研究的目的:
- 为了研究血清卡尔格兰林C作为IBD诊断的非侵入性生物标志物.
- 与现有的生物标志物和内镜评分相比,评估其在预测疾病活动和严重性方面的作用.
- 评估其在性结肠炎和克罗恩病患者的缓解监测中的实用性.
主要方法:
- 该研究包括80名IBD患者 (50名性结肠炎,30名克罗恩氏病患者) 和20名对照患者.
- 测量了血清卡尔格拉努林C,便calprotectin,CRP,ESR和全血细胞计.
- 使用结肠镜检查,组织病理学,并建立了活动评分系统 (UC的ACG,CD的CDAI).
主要成果:
- 与对照人群相比,UC和CD患者的血清卡尔格兰林C水平显著升高.
- 在UC中,血清calgranulin C和便calprotectin与疾病严重程度相关 (轻度与中度/严重/缓解).
- 在CD中,血清calgranulin C和便calprotectin在活跃疾病和缓解中显着更高.
结论:
- 血清卡尔格拉努林C作为IBD的一个有价值的非侵入性生物标志物.
- 它可以有效地预测性结肠炎和克罗恩病的疾病活动和严重程度.
- 这种生物标志物有助于确保IBD患者的缓解和监测疾病状态.
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