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Updated: Jun 21, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

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一个精心策划的旋转细胞库,用于蛋白质的常见翻译后修改

Oufan Zhang1, Shubhankar A Naik2, Zi Hao Liu3,4

  • 1Kenneth S. Pitzer Center for Theoretical Chemistry, University of California, Berkeley, CA 94720, United States.

Bioinformatics (Oxford, England)
|July 12, 2024
PubMed
概括

这项研究引入了新的侧链旋转子库,用于蛋白质的翻译后修饰 (PTM). 这些库增强了用PTMs预测蛋白质结构,并有助于建模内在无序蛋白质 (IDPs).

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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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