贫困和社区机会对新生儿的影响DNAm发育年龄
Stefanie R Pilkay1, Anna K Knight2, Nicole R Bush3,4
1School of Social Work, Syracuse University, Syracuse, New York, United States of America.
PloS one
|July 12, 2024
概括
社区机会可以缓冲低家庭收入对婴儿发育的负面影响. 更高的社区教育机会与高收入母亲的婴儿的更低的妊娠年龄加速有关,而社会/经济机会有利于低收入地区的男性.
科学领域:
- 表观遗传学和发育生物学
- 健康的社会经济决定因素
- 环境对发展的影响环境对发展的影响
背景情况:
- 低社会经济地位 (SES) 与儿童不良结果有关,包括较高的死亡率和行为问题.
- 产前暴露于低收入与表观遗传变化有关,影响后代从出生开始的发育.
- 社区特点可能会减轻低家庭收入对健康的一些负面影响.
研究的目的:
- 调查邻里机会是否能缓和家庭收入 (HI) 与新生儿发育成熟度之间的关联.
- 评估童年机会指数 (COI) 与产前HI和发育表观遗传标记有关的作用.
主要方法:
- 带血DNA甲基化数据的分析,来自198个母亲-新生儿对.
- 使用新生儿表观遗传钟计算妊娠年龄加速.
- 产前HI和COI对妊娠年龄加速的回归分析,控制共变量.
主要成果:
- 较高的家庭收入 (HI) 与更大的妊娠年龄加速相关.
- 相互作用效应表明,较高的社区教育机会与中度至高HI家庭新生儿的更低的妊娠年龄加速有关.
- 更高的社会和经济社区机会与男性新生儿更大的妊娠年龄加速有关.
结论:
- 产前家庭收入和邻居因素影响出生时妊娠年龄加速.
- 邻居品质是减轻家庭收入差异对产前发育影响的潜在政策途径.
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