饮食中的叶酸摄入量与HPV感染之间的关联:NHANES 2005-2016年
Shuo Jin1,2, Fangxuan Lin1,2, Liuqing Yang1,2,3
1Department of TCM Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
PloS one
|July 12, 2024
概括
更高的食叶酸摄入量与人类乳头瘤病毒 (HPV) 感染的风险降低有关. 这种反向关系是非线性的,随着叶酸消费的增加而变得更加明显.
科学领域:
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 宫癌与叶酸水平和人类乳头瘤病毒 (HPV) 感染有关.
- 饮食中的叶酸与HPV感染之间的关系需要进一步调查.
研究的目的:
- 为了检查饮食中的叶酸摄入量与HPV感染之间的关联.
- 探索潜在的非线性相关性和子组差异.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2005-2016).
- 采用多变量逻辑回归和受限立方线 (RCS).
- 对不同种群进行了子组分析.
主要成果:
- 叶酸摄入量增加1微克与HPV发病率减少1%相关 (OR=0.99,p<0.05).
- 较高的叶酸摄入四分位数显示出显著的反向关联,特别是Q4 (OR=0.63).
- 非线性关联得到证实,明显的反相关性高于193.847mcg/day.
结论:
- 饮食中的叶酸摄入与HPV感染风险有负面关联.
- 这种关联表现出非线性模式,特别是在更高的摄入量水平.
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