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Updated: Jun 21, 2025

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Published on: February 28, 2019

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MHC异性限制了CD4 T细胞中T细胞受体的变异性

Alexander J Brown1,2, Janice White1, Laura Shaw1

  • 1Department of Immunology and Genomic Medicine, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.

Science immunology
|July 12, 2024
PubMed
概括

具有多种主要基因相容性复合体 (MHC) 基因基因的小鼠具有较少的T细胞受体 (TCR) 多样性. 胸腺选择过程意外地减少了MHC异构菌的TCR谱系多样性,尽管有潜在的好处.

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