在癌症治疗中使用原药启发的腺三酸盐可激活的罗-Fe (III) 酸盐
Hanrong Li1,2, Yifan Li1,2, Lingpu Zhang1,3
1College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Science advances
|July 12, 2024
概括
这项研究开发了新的Celastrol-铁纳米粒子 (CEL-Fe NPs),以增强癌症治疗. 智能纳米颗粒可以改善Celastrol.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 塞拉斯 (CEL) 显示出强大的抗癌活性,但其稳定性和毒性不佳.
- 现有的局限性阻碍了塞拉斯特在癌症治疗中的临床应用.
研究的目的:
- 设计和合成CELASTROL的智能药物输送系统.
- 为了提高塞拉斯特的生物安全性和生物可用性,用于增强癌症治疗.
主要方法:
- 开发了一种可激活的腺三酸盐 (ATP) 可激活的CELASTROL-Fe (III) 酸盐.
- 将酸盐封装在反应性氧物种 (ROS) 响应的聚合物中,形成CEL-Fe纳米粒子 (CEL-Fe NP).
- 在瘤微环境中评估纳米粒子稳定性,药物释放和抗瘤疗效.
主要成果:
- 在正常组织中,CEL-Fe NP显示结构稳定性和降低系统性毒性.
- 在瘤微环境中,ROS触发了药物释放,ATP结合恢复了抗瘤功效.
- 智能输送系统显著改善了塞拉斯特的生物利用率和治疗指数.
结论:
- 开发的CEL-FeNP代表了一种有效的策略,可以克服塞拉斯特的局限性.
- 这种Celastrol-金属酸盐方法为开发新型癌症疗法提供了一个有前途的平台.
- 该战略扩大了Celastrol衍生物在临床使用中的治疗潜力.
更多相关视频
09:00An In Vitro Enzymatic Assay to Measure Transcription Inhibition by GalliumIII and H3 5,10,15-trispentafluorophenylcorroles
Published on: March 18, 2015
11.5K
10:54Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
8.2K
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K