相关实验视频

Updated: Jun 21, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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在IRF8突变B细胞淋巴瘤中,通过CD74依赖的抗原处理和呈现在MHCII复合体中的放松调节来逃避免疫力

Zhijun Qiu1, Jihane Khalife1, Purushoth Ethiraj1

  • 1Division of Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.

Science advances
|July 12, 2024
PubMed
概括

淋巴瘤中的干扰素调节因子8 (IRF8) 突变会损害抗原呈现,导致免疫逃避. 这项研究揭示了IRF8变异如何促进瘤生长并改变瘤微环境,有助于扩散大B细胞淋巴瘤 (DLBCL) 的进展.

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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

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