腹腔透析患者认知障碍和潜在风险因素的研究:一项观察性研究
Chunxia Shi1, Shujing Jia2, Xiaoqi Wang1
1Department of Nephrology, Beijing Lu-He Hospital, Capital Medical University, Beijing, China.
Medicine
|July 12, 2024
概括
认知障碍 (CI) 影响超过一半的腹腔透析患者. 关键的危险因素包括男性性别,年龄较大和高胆固醇,而残留的功能提供了保护.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 认知障碍 (CI) 是接受置换治疗的患者的一个重大问题.
- 腹腔透析 (PD) 患者可能面临独特的认知衰退风险,原因是与末期脏疾病和透析本身相关的因素.
研究的目的:
- 调查持续门诊腹膜透析 (CAPD) 患者中CI的患病率.
- 确定影响该人口认知功能的相关风险因素和保护因素.
主要方法:
- 从2020年1月到2023年9月对268名CAPD患者的回顾性分析.
- 使用蒙特利尔认知评估尺度评估认知功能.
- 生物标志物分析和认知障碍和正常群体之间的比较.
主要成果:
- 在CAPD患者中,CI的患病率为58.2%.
- CI组的酒精消费量较高,教育程度较低,血清尿酸减少,自身免疫性疾病发病率较高.
- 在CI组中观察到总胆固醇升高,血清水平降低,以及更高的高灵敏度C反应蛋白.
- CI的独立风险因素包括男性性别,年龄较大,教育程度较低,高胆固醇血症和hs-CRP升高.
- 透析持续时间和残留功能是预防CI的保护因素.
结论:
- 在CAPD患者中,认知障碍非常普遍.
- 特定的临床和生化标志物与风险增加有关.
- 维持残留功能和管理高胆固醇血症等危险因素对于保持PD患者的认知健康至关重要.
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