血清与非酒精性脂肪肝疾病之间的关联:来自NHANES的结果:一项观察性研究
1Department of Spleen, Stomach, Liver and Gallbladder Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Medicine
|July 12, 2024
概括
高水平与非酒精性脂肪性肝病 (NAFLD) 患病率增加相关,但男性和女性的晚期肝纤维化 (AHF) 风险降低. 这项研究探讨了和肝脏健康标志物之间的复杂关系.
科学领域:
- 肝病学和营养科学 肝病学和营养科学
- 临床研究 临床研究
- 流行病学 流行病学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是一种普遍存在的肝病,晚期肝纤维化 (AHF) 表明疾病进展.
- (Se) 是一种必不可少的微量元素,但过量摄入可能是有毒的.
- 血清Se水平在性别之间有所不同,男性通常具有更高的水平.
研究的目的:
- 调查血清水平与NAFLD和AHF的患病率之间的相关性.
- 为了检查这些跨性别的相关性.
主要方法:
- 利用了2017-2020年国家健康和营养检查调查 (NHANES) 7271名参与者的数据.
- 采用描述性分析,多变量逻辑回归,子组分析,相互作用分析和受限立方线回归.
- 分析了血清Se水平与NAFLD/AHF患病率之间的关系,并调整了混因素.
主要成果:
- 与非NAFLD组相比,男性和女性NAFLD组的血清Se水平显著更高.
- 在男性中,血清Se四分位数增加与NAFLD患病率上升17.6%,AHF患病率下降38.5%有关.
- 在女性中,血清Se四分位数增加与NAFLD患病率上升29.1%,AHF患病率下降51.6%有关.
结论:
- 血清Se水平与两性NAFLD患病率呈正相关性.
- 血清Se水平与两性AHF患病率存在负相关性.
- 这些发现表明在NAFLD中的复杂性,性别特异性作用及其进展到晚期纤维化.
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