代谢功能障碍相关的肝病和糖尿病:矩阵重塑,纤维化和治疗影响
Weiguo Fan1,2, Toby M Bradford1, Natalie J Török1,2
1Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Annals of the New York Academy of Sciences
|July 12, 2024
概括
与代谢功能障碍相关的肝病 (MASLD) 和脂肪肝炎 (MASH) 在全球范围内正在上升. 早期检测和抗纤维菌疗法对于治疗肝纤维化至关重要,特别是在糖尿病患者中.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 胃肠病学 胃肠病学
背景情况:
- 由于肥胖和糖尿病流行病,代谢功能障碍相关的肝病 (MASLD) 和脂肪肝炎 (MASH) 正在全球范围内增加.
- MASLD影响着数百万,到2030年估计会有1亿个病例,特别影响2型糖尿病患者.
- MASH是一种MASLD的进展,涉及肥胖症,死体炎症和潜在的纤维化导致肝硬化.
研究的目的:
- 突出MASLD和MASH的日益增长的患病率和风险,特别是在糖尿病人群中.
- 强调需要改善MASLD/MASH的诊断方法和早期检测策略.
- 强调需要开发有效的抗纤维菌疗法来预防和逆转肝纤维化.
主要方法:
- 审查有关MASLD和MASH流行情况的当前流行病学数据.
- 分析疾病进展途径,包括遗传,表观遗传和细胞因素.
- 对MASLD/MASH.的药物开发和临床试验进展的审查.
主要成果:
- MASLD和MASH是全球慢性肝病的主要原因.
- 糖尿病患者表现出加速的疾病进展和更高的风险.
- 纤维化和 stromal 重塑涉及复杂的遗传和细胞矩阵相互作用.
结论:
- 迫切需要改善MASLD/MASH的诊断和早期检测.
- 开发能够逆转纤维化的抗纤维菌疗法至关重要.
- 解决MASLD/MASH的复杂性需要多方面的方法,包括治疗干预.
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