在诊断早期结肠直肠癌之前使用处方药的模式:基于人口的描述性研究
Vienna Cheng1,2, Eric C Sayre3, Vicki Cheng1,2
1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
JMIR cancer
|July 12, 2024
概括
被诊断为早期结直肠癌 (EAO-CRC) 的患者在诊断前一年经常使用处方药. 这些药物治疗了常见的EAO-CRC症状,表明了潜在的诊断延迟.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 结肠直肠癌 (CRC) 是加拿大的重大健康问题,排名第四最常见的癌症诊断.
- 早期发病的结直肠癌 (EAO-CRC) 的增加令人担忧,在50岁以下的个人中诊断出这种癌症.
- 了解EAO-CRC的诊断过程是非常重要的,因为它的发病率越来越高.
研究的目的:
- 调查在EAO-CRC诊断之前的一年内处方药的使用模式.
- 为了将EAO-CRC患者的药物使用与无癌症对照进行比较.
- 在诊断前的处方数据中识别EAO-CRC的潜在指标.
主要方法:
- 在加拿大不列颠哥伦比亚省利用了链接的行政健康数据库.
- 在2010年至2016年间诊断的EAO-CRC确诊病例与无癌症对照组相匹配 (1:10).
- 分析了在诊断前一年填写的所有社区药房处方,按解剖治疗化学分类系统3级分类.
主要成果:
- 分析了1001个EAO-CRC病例,其中79.7%在诊断前一年填写了12989份处方.
- 抗抑郁药是最常见的药物类别 (13.1%).
- 与对照组相比,EAO-CRC病例更有可能填写胃/GERD (OR 1.4) 和疹/裂治疗 (OR 7.4) 的处方.
结论:
- 在EAO-CRC诊断前一年观察到经常使用处方药,包括用于症状管理.
- 治疗胃肠道症状和的药物在EAO-CRC病例中明显更常见.
- 这些发现突出了处方数据的潜力,以告知EAO-CRC的早期识别.
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