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对于外围神经再生的脚手架设计考虑因素

Le Yu1, Carly Jane Bennett1, Chung-Hsun Lin1

  • 1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, United States of America.

Journal of neural engineering
|July 12, 2024
PubMed
概括

可生物降解的神经引导管道 (NGCs) 为神经自移植提供了一个有希望的替代方案,用于修复外围神经损伤 (PNI). 正在开发先进的功能NGC来改善神经再生,解决当前治疗方法的局限性.

关键词:
神经引导管道的神经引导管道外围神经的再生和再生脚手架的设计设计.组织工程是组织工程.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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