肥胖丰富的肠道微生物降解肌胺醇,并促进脂质吸收
Chao Wu1, Fangming Yang2, Huanzi Zhong2
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
一种特定的肠道细菌,Megamonas,与肥胖有关. 它降解了myo-inositol,增强了脂肪的吸收并促进了体重增加,提供了潜在的肥胖管理目标.
科学领域:
- 微生物学 微生物学
- 转基因组学是指转基因组学.
- 肥胖问题研究研究
背景情况:
- 肠道微生物群在肥胖中起作用,但具体的致病微生物和机制尚不清楚.
- 识别导致肥胖的微生物贡献者对于制定有效的管理策略至关重要.
研究的目的:
- 为了确定特定的肠道微生物因果关系与肥胖在中国队列.
- 阐明这些微生物导致肥胖的机制,重点关注代谢途径.
主要方法:
- 在631名肥胖者和374名体重正常的个体上进行了枪支元基因组测序.
- 在体外和体内实验被用来评估已识别的微生物及其代谢产品的功能.
- 动物模型 (老鼠) 被殖民,以研究对脂质吸收和肥胖的影响.
主要成果:
- 一个由Megamonas主导的肠型集群在肥胖者中得到了丰富.
- 梅加莫纳斯鲁佩伦辛斯会降解肌体内醇,而这一过程会抑制脂肪酸的吸收.
- 被M. rupellensis殖民的小鼠显示肠道脂质吸收和肥胖的增强.
结论:
- 梅加莫纳斯鲁佩伦辛斯通过降解myo-inositol,从而增强肠道脂质吸收,从而导致肥胖.
- 这一发现表明M. rupellensis是肥胖管理的潜在治疗点.
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