心脏纤维化表观遗传调节中的当前概念
Ali Fatehi Hassanabad1, Anna N Zarzycki1, Vaibhav B Patel2
1Section of Cardiac Surgery, Department of Cardiac Science, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
概括
心脏纤维化是心力衰竭的关键因素,受表观遗传变化的影响. 外体和非编码RNA在调节这些纤维化过程中发挥着作用.
科学领域:
- 心血管生物学 心血管生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子医学是分子医学.
背景情况:
- 心脏纤维化是导致充血性心力衰竭的主要原因之一.
- 纤维化涉及复杂的转录,受体和信号通路.
- 在心脏纤维化进展中,表观遗传修饰越来越多地被认可.
研究的目的:
- 审查外体在心脏纤维化中的作用.
- 为了确定参与亲和抗纤维菌通路的转录因子.
- 探索调解剂作为诊断或预后生物标志物的潜力.
主要方法:
- 综合性文献综述,重点关注外体,微RNA和长非编码RNA.
- 对调节纤维细胞路径的转录因子的分析.
- 对生物标志物潜力的当前数据的评估.
主要成果:
- 外基因组,微RNA和长非编码RNA影响心脏纤维化表观遗传学.
- 特定的转录因子表现出亲纤维菌或抗纤维菌的特性.
- 有证据支持某些介质作为生物标记物的实用性.
结论:
- 通过非编码RNA和外体的表观遗传调制在心脏纤维化中至关重要.
- 需要进一步的研究来转化发现,以改善临床结果.
- 外体有望作为心力衰竭的诊断和预后工具.
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