Tagetes erecta L.: 一种在治疗炎症过程中有效的传统医学
Carlos Rafael Vaz1, Larissa Benvenutti1, Fernanda Capitânio Goldoni1
1Postgraduate Program in Pharmaceutical Science, Universidade do Vale do Itajaí, Itajaí, Santa Catarina, Brazil.
Journal of ethnopharmacology
|July 12, 2024
概括
提取Tagetes erecta提取物,或阿兹特克,通过抑制中性粒细胞活动和增强细胞分裂,减少炎症. 这项研究揭示了其作为急性疾病的天然抗炎剂的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 民族植物学 民族植物学
背景情况:
- Tagetes erecta L. (Asteraceae),或阿兹特克,传统上用于炎症状况.
- 其精确的抗炎机制,特别是对中性粒细胞和巨细胞的作用,需要进一步研究.
研究的目的:
- 为了研究含水醇的Tagetes erecta提取物的抗炎作用.
- 阐明它对中性粒细胞和巨细胞功能的作用机制.
主要方法:
- 在体外分析细胞因子 (TNF,IL-6,CXCL-1,IL-1β,IL-10) 和氧化 (NO) 生产,粘附分子表达,以及LPS刺激的中性粒细胞和巨细胞中的化学反应.
- 在体内评估卡拉诱导的小鼠模型中的抗炎活性,测量白细胞流入,介质分泌和蛋白质排泄.
主要成果:
- 提取物抑制了中性粒细胞化学反应,并在体外减少了促炎性细胞因子和NO的产生.
- 它增强了阿波性中性粒细胞的巨细胞增生,增加了IL-10和降低了TNF.
- 在体内研究证实白细胞迁移,蛋白质排泄和炎症媒介的减少.
结论:
- 泰吉特勃起的提取物具有显著的抗炎性质.
- 它调节炎症媒介,限制中性粒细胞迁移,并促进细胞增生.
- 这些发现支持其作为急性炎症的天然治疗方法的潜在用途.
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