芯片上传感器的超频阵列用于高通量电化学分析
Lucas B Ayres1, Gabriel J C Pimentel2,3, Juliana N Y Costa2,4
1Department of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
ACS sensors
|July 12, 2024
概括
本研究介绍了一种低成本,高通量电化学传感器阵列,用于快速诊断. 这种新的设计使多个样本的连续或同时分析成为可能,提高了用于细菌检测和COVID-19查等应用的测试能力和准确性.
科学领域:
- 电化学 电化学 电化学
- 生物感应是一种生物感应.
- 材料科学 材料科学 材料科学
背景情况:
- 高通量传感器对于快速准确的诊断至关重要.
- 现有的电化学设备往往缺乏简单性和成本效益,以适应大规模使用.
- 开发高效的传感器阵列是提高诊断能力的关键.
研究的目的:
- 为了展示一种简单,低成本,高密度的垂直金薄膜微电极式传感器阵列.
- 为了使多个样本的快速和串行查询使用一个紧的芯片.
- 制定一项战略,克服交叉通话干扰并提高测试能力.
主要方法:
- 为48个传感器设计了一个3D横杆布局,其中有16个工作超微电极 (UME) 和3个准参考电极 (QRE).
- 采用 chronoamperometry 和方波电压测量,并使用手持电位器进行分析.
- 开发并实施了纠正策略,包括将未使用的QRE行接地以减轻交叉通话.
主要成果:
- 在14分钟内在15个样本中成功检测到金黄色葡萄球菌.
- 在使用结免疫传感器从患者血清样本中查COVID-19时实现了100%的准确性.
- 在实施交叉声调整策略后大约8分钟内,同时对48个样本进行了分析.
结论:
- 开发的微电极阵列为电化学诊断提供了高通量,低成本的解决方案.
- 交叉通话缓解策略显著提高了传感器阵列的测试能力.
- 该平台广泛适用于开发基于超微电极的先进,高通量传感器.
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