在患有精神疾病的COVID-19幸存者中,优先和持续的血小板激活
Norma Maugeri1,2, Rebecca De Lorenzo3,4, Mario Gennaro Mazza3,5
1Vita-Salute San Raffaele University, Milan, Italy. maugeri.norma@hsr.it.
Scientific reports
|July 12, 2024
概括
患有精神疾病的患者在COVID-19后表现出独特的血小板激活,增加了风险. 这表明精神疾病,SARS-CoV-2和通过血栓炎症的严重结果之间存在联系.
科学领域:
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
- 心血管科学 心血管科学
背景情况:
- 预先存在的精神障碍与严重的COVID-19结局有关,可能是由于血管负担增加.
- COVID-19的特点是异常的血小板激活,导致炎症和血栓形成.
- 精神疾病的炎症理论表明,精神疾病和SARS-CoV-2诱导的血小板激活之间存在潜在的联系.
研究的目的:
- 为了调查COVID-19幸存者的血小板激活,无论是否有先前存在的精神障碍.
- 探索精神病诊断与与SARS-CoV-2相关的血小板反应之间的关联.
主要方法:
- 研究了141名COVID-19幸存者一个月后病毒清除.
- 在DSM-5诊断精神障碍的人和没有精神障碍的人之间比较血小板激活模式.
- 使用通用线性模型 (GLZM) 进行多变量分析,控制年龄和性别.
主要成果:
- 患有精神疾病史的患者的血小板表现出偏好的非常规激活.
- 在没有精神病诊断的患者中没有观察到这种偏好激活.
- 多变量分析证实了精神病诊断对血小板激活的显著影响,独立于年龄和性别.
结论:
- 患有先前存在的精神疾病的患者在急性COVID-19期间表现出优先血小板激活.
- 这种激活是由血栓炎症机制调解的.
- 这一发现可能解释了精神病患者中严重COVID-19结果的风险增加.
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