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Updated: Jun 21, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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通过将溶解数据纳入PBPK建模中,确定欧美普拉肠涂层囊的虚拟生物等价性和临床相关规范

Ruwei Yang1, Yaqi Lin1, Kaifeng Chen1

  • 1Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China.

The AAPS journal
|July 12, 2024
PubMed
概括

这项研究开发了基于生理学的药理动力学 (PBPK) 模型和虚拟生物等价性 (VBE) 方法,用于肠膜涂层梅囊. 这些模型为通用欧米醇建立了临床相关的溶解规格,可能为BCSII类药物提供生物豁免.

关键词:
在体外-体外关系的关系.生物等价性 生物等价性临床相关的溶解规范.奥梅普拉佐尔肠上涂层囊 肠上涂层囊基于生理学的药物动力学建模.

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