相关实验视频

Updated: Jun 21, 2025

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

设计的实验驱动优化喷雾干燥的无形克洛特里马纳米悬浮的设计实验

Bhavin Gajera^1,2, Harsh Shah^1,3, Bhavin Parekh¹

¹Division of Pharmaceutics Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, The Long Island University, Brooklyn, NY, 11201, USA.

AAPS PharmSciTech

|July 12, 2024

概括

这项研究使用设计质量优化了无形克洛特里马纳米悬浮,实现了更高的溶解速率. 喷雾干燥的克洛特里马纳米悬浮体显示出由于其纳米尺寸的无形粒子而提高了生物可用性.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

克洛特里马 (CLT) 是一种抗真菌剂,可溶性差.
开发无形纳米悬浮剂可以增强药物溶解和生物可用性.
设计质量 (QbD) 提供了一种系统的方法来优化制药过程.

研究的目的:

使用喷雾干燥开发和优化无形克洛特里马纳米悬浮剂 (CLT-NS).
调查过程参数对CLT-NS的关键质量属性 (CQAs) 的影响.
评估优化的CLT-NS的物理化学特性和体外溶解.

主要方法:

通过设计质量 (QbD) 方法使用盒式设计 (BBD).
使用Soluplus®和微晶纤维素喷雾干燥无形克洛特里马纳米悬浮.
使用X射线粉末衍射 (XRPD),FTIR,DSC和体外溶解研究进行分析.
回归分析和ANOVA用于识别重要因素和相互作用.

主要成果:

进口温度,料速率和吸收速率被确定为影响产量,再分散性指数 (RDI) 和水分含量的重要因素.
优化的CLT-NS表现出一种无形状态,由XRPD和DSC证实.
FTIR证实,CLT与辅助剂之间没有化学相互作用.
在体外溶解研究显示,DI水增加了3.12倍,pH值7.2.2时增加了5.88倍.

结论:

QbD方法成功优化了无形克洛特里马纳米悬浮的喷雾干燥过程.
优化的CLT-NS显示了纳米尺寸无形粒子的显著改善的溶解速率.
这种配方有可能提高克洛特里马的治疗疗效.

关键词:

没有形态的无形.美国能源部 (DoE)这是一种纳米悬浮.在QbD中,它是QbD.喷雾干燥喷雾干燥

更多相关视频

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Published on: December 9, 2010

A System to Create Stable Nanoparticle Aerosols from Nanopowders

A System to Create Stable Nanoparticle Aerosols from Nanopowders

Published on: July 26, 2016

相关概念视频

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...