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高效和稳定的NIR-II金属分子寡合体光,用于体内单细胞跟踪和时间分辨率成像
1Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and Chem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433, China.
Angewandte Chemie (International ed. in English)
|July 12, 2024
概括
研究人员开发了明亮,稳定的分子光,用于深层组织成像. 新的异诺 (I) 复合物在第二次近红外窗口 (NIR-II) 中显示长寿命的辐射,使得体内生物跟踪和高对比度成像成为可能.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学成像技术 生物医学成像技术
- 摄影化学的使用.
背景情况:
- 第二次近红外 (NIR-II) 分子光通过减少背景光提供深层组织成像潜力.
- 开发用于生物应用的明亮和稳定的NIR-II光剂是一项挑战.
研究的目的:
- 合成新型的异 (I) 复合物,用于明亮而稳定的NIR-II分子光.
- 评估它们对深层组织光学成像和体内生物应用的潜力.
主要方法:
- 合成了对称的异诺 (I) 复合体,配有量身定制的连接物替代剂.
- 在水溶液中和与胎儿牛血清 (FBS) 结合后研究了光特性.
- 在生物环境中评估稳定性,量子产量和排放寿命.
主要成果:
- 通过金属友好相互作用,形成了形成具有明亮,长寿命 (7-8μs) 光的寡合体的异 (I) 复合体.
- 优化的配体增强了分散吸引力和电子捐赠特性,扩展波长和稳定性.
- 与FBS结合的寡合物表现出高量子产量 (高达3.93%) 和长期稳定性.
- 启用单个巨细胞动态和高对比度时间分辨率成像的体内追踪.
结论:
- 新型异 (I) 复合物为高效的NIR-II分子光提供了一个有前途的平台.
- 这些材料展示了先进深层组织光学成像和生物医学应用的潜力.
- 开发的光剂为体内追踪和诊断提供了增强的稳定性和亮度.
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