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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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相关实验视频

Updated: Jun 21, 2025

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连接体梯度功能障碍有助于白质过强度相关的认知衰退.

Dan Yang1,2, Yi Tan2, ZhiXin Zhou1,2

  • 1Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.

CNS neuroscience & therapeutics
|July 13, 2024
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概括

白质高强度 (WMH) 减小体积影响大脑网络梯度和认知衰退. 具体来说,WMH进展缩小了初级到跨模态梯度,损害了执行功能和处理速度.

关键词:
认知能力下降 认知能力下降执行职能 执行职能是指执行职能.功能连接组的梯度渐变.白质超强度是白质的超强度.

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科学领域:

  • 神经成像是一种神经成像.
  • 认知神经科学 认知神经科学
  • 神经学 神经学

背景情况:

  • 白质过强度 (WMH) 与认知能力下降有关,但潜在的机制尚不清楚.
  • 功能性大脑网络表现出从感觉到认知的初级到跨模态梯度.
  • 目前尚不清楚WMH进展如何改变这种梯度并影响认知.

研究的目的:

  • 为了研究WMH体积和功能连接体梯度结构之间的关系.
  • 探索主要到跨模态梯度的变化如何与WMH个体的认知功能有关.

主要方法:

  • 在758名WMH患者中利用休息状态功能性MRI (rs-fMRI).
  • 使用梯度分解框架重建了功能连接体梯度.
  • 分析了WMH分布,梯度测量和认知领域之间的关联.

主要成果:

  • 增加WMH体积与较差的执行功能和处理速度相关.
  • 随着WMH的进展,初级到跨模态梯度的范围和差异减少了.
  • 较窄的梯度范围和较小的差异与较差的执行功能有关.

结论:

  • 总体而言,WMH体积,初级到跨模态梯度和认知是相互关联的.
  • WMH对执行功能产生负面影响,部分是由于降低梯度差异的介导.
  • 研究结果强调了改变大脑网络组织在WMH相关认知障碍中的作用.