对青少年肥胖对心室再极化影响的评估
Alaaddin Yorulmaz1, Ahmet Sert2, Fuat Bugrul3
1Department of Paediatrics, Selcuk University, Faculty of Medicine, Konya, Turkey.
Journal of electrocardiology
|July 13, 2024
概括
与健康的同龄人相比,肥胖的青少年表现出延长的Tp-Te间隔,这是心室复极化的标志物. 这一发现突显了青少年肥胖的潜在心脏风险,特别是代谢综合征.
科学领域:
- 心脏病学 心脏病学
- 儿科 儿科 儿科
- 电子生理学 电子生理学
背景情况:
- 在患有代谢综合征的肥胖青少年中,对心室再极化参数,特别是Tp-Te间隔和Tp-e/QT比率的研究有限.
- 腹腔再极化异常可能会在这个人群中导致心血管风险.
研究的目的:
- 为了比较腹腔再极化参数,包括Tp-Te间隔和Tp-e/QT比率,在肥胖的青少年和没有代谢综合征与健康的对照组.
- 调查这些再极化参数与心血管风险因素和心声图变量之间的关联.
主要方法:
- 一项涉及100名肥胖青少年和50名瘦身对照者的研究.
- 肥胖的参与者根据代谢综合征的存在或不存在被分为子组.
- Tp-Te 间隔被定义为从T波峰值到T波结束在心电图上的时间.
主要成果:
- 肥胖的青少年,无论是有还是没有代谢综合征,与对照人群相比,其QTc和TpTe间隔显著增加.
- 在肥胖子组和对照组之间,没有发现QT分散,QTc分散,TpTe分散或TpTe/QT比率的显著差异.
- 具体来说,TpTe值在肥胖非代谢综合征组中升高,与对照组相比,肥胖代谢综合征组的最低TpTe值升高.
结论:
- 与健康个体相比,肥胖青少年的Tp-Te间隔较高,表明心室再极化发生变化.
- 在肥胖和对照组之间没有观察到Tp-Te分散或Tp-Te/QT比率的显著差异.
- 在代谢综合征的肥胖青少年中,Tp-Te与HDL胆固醇之间存在负相关性,Tp-Te/QT比率与胰岛素敏感性之间存在正相关性.
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