不同的基础效应是家猫主导蓝眼 (DBE) 的基础
Marie Abitbol1,2, Caroline Dufaure de Citres3, Gabriela Rudd Garces4
1Univ Lyon, VetAgro Sup, 69280 Marcy-l'Etoile, France.
Animals : an open access journal from MDPI
|July 13, 2024
概括
在Paired Box 3 (PAX3) 基因中出现了一种新的逆转录病毒插入,导致猫的蓝眼占主导地位 (DBE). 这种遗传变异解释了几种品种的特征,但存在其他导致猫主导蓝眼的原因.
科学领域:
- 遗传学 是一个遗传学.
- 动物育种 动物育种
- 分子生物学分子生物学
背景情况:
- 微小的白斑与蓝色的眼睛是猫科动物繁殖中选择的特征.
- 主导蓝眼 (DBE) 是一种在各种猫种中观察到的自体主导特征.
- 以前的研究将两种PAX3基因变异与特定猫系中的DBE联系起来.
研究的目的:
- 为了确定在英国猫中占主导地位的蓝眼 (DBE) 的遗传原因.
- 调查不同猫科动物血统中DBE的遗传基础.
- 为了确定在DBE猫中发现的PAX3变异的流行率.
主要方法:
- 全基因组关联研究 (GWAS) 定位与DBE相关的遗传区域.
- 全基因组测序以确定候选基因区域内的变异.
- 在14个血统中对117只DBE猫进行基因定型,以验证变异关联.
主要成果:
- 英国猫的DBE与C1染色体上的单一区域有关,这涉及PAX3基因.
- 在PAX3内4的逆转录病毒LTR插入 (NC_018730.3:g.206975776_206975777insN[433]) 被确定为英国,阿尔泰和其他血统中DBE的原因.
- 这种PAX3变异在测试的血统中与DBE完全相关,被提出为阿尔泰主导蓝眼 (DBE) 基因.
- 在14个DBE谱系中,有4个缺少了三种已识别的PAX3变异,这表明了遗传异质性.
结论:
- 在PAX3基因中特定的逆转录病毒插入被确定为多种家猫系中占主导地位的蓝眼睛的原因.
- 猫中主导蓝眼的遗传异质性得到证实,可能存在其他致病变体.
- 这一发现促进了对猫毛色遗传学和特定品种特征的理解.
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