饮食中的对肉免疫反应,抗氧化功能和肉骨结构的影响
Zesheng Yin1, Xue Sun1, Xuehong Chai1
1College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Animals : an open access journal from MDPI
|July 13, 2024
概括
在 brojler 料中补充 Pterostilbene (PTE) 可以增强免疫功能和肠道健康. 这项研究发现,PTE减少了炎症,并提高了Arbor Acres肉的抗氧化能力.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 肉生产面临与免疫功能和肠道健康相关的挑战.
- 固醇 (PTE),一种天然化合物,显示出改善动物健康的潜力.
- 优化肉饮食对于提高生长性能和抗病能力至关重要.
研究的目的:
- 为了研究饮食中的氏 (PTE) 对血清生物化学参数,免疫和炎症反应,抗氧化剂状态和阿伯尔艾克斯肉肠道形态的影响.
- 确定PTE的最佳剂量,以改善肉的健康和表现.
- 阐明PTE对 brojler免疫力和肠道健康有益影响的分子机制.
主要方法:
- 480只Arbor Acres肉在42天内被食基础饮食,并补充了0, 200, 400或600毫克/公斤PTE.
- 评估了血清生物化学参数,免疫细胞活性 (淋巴细胞转化率),炎症标志物 (细胞因子,基因表达) 和抗氧化酶活性 (CAT,GSH-Px,T-SOD).
- 评估了肠道形态 (维利高度,密室深度) 和肠道屏障功能 (紧结蛋白的基因表达,NF-κB信号通路).
主要成果:
- 补充PTE,特别是400 mg/kg,显著增加了淋巴细胞转化率和血清补充C3和IL-4水平.
- PTE降低了促炎性细胞因子 (IL-6,TNF-α) 和相关基因表达,并降低了MDA含量,表明氧化应激减少.
- 观察到改善了骨抗氧化酶活动,增强了骨高度与密室深度的比率,并上调了紧结蛋白表达 (Claudin-2,Occludin,ZO-1).
结论:
- 食士补充剂有效地改善了 brojlers 的免疫功能和抗氧化剂状态.
- PTE通过减少炎症,增加抗氧化能力和改善肠道屏障完整性来增强肠道健康.
- 这些发现表明PTE是一种有益的料添加剂,可以促进肉的健康,并可能提高生产效率.
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