微藻衍生阿斯塔桑的使用,以提高热感应氧化压力肉的乳房中的细胞保护能力
Donna Lee Kuehu1,2, Yuanyuan Fu1, Masaki Nasu1
1Bioinformatics Core, Department of Quantitative Health Sciences, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Animals : an open access journal from MDPI
|July 13, 2024
概括
补充阿斯塔丁可以通过调节骨中的细胞保护性和上皮完整性基因来减轻 brojlers 的热应激. 这种抗氧化剂治疗在热应激条件下提供了增强细胞保护和平衡的潜力.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 分子生物学分子生物学
背景情况:
- 胃肠道,特别是大肠,对于营养吸收,免疫功能和维持平衡至关重要.
- 热应激通过氧化损害对肉的表现和肠道健康产生负面影响.
- 作为一种强有力的抗氧化剂,阿斯塔克桑丁因其对抗细胞压力的保护作用而受到研究.
研究的目的:
- 为了研究热引起的氧化应激对 brojiler ileum的影响.
- 评估阿斯塔克桑治疗对肉热应激的缓解作用.
- 分析与细胞保护和上皮完整性相关的基因表达特征.
主要方法:
- 肉被分为三组:热中性,热应激和与阿斯塔克桑有关的热应激.
- 温度保持在21-22°C (热中性) 和32-35°C (热应激).
- 分析了生长表现和阴道基因表达 (细胞保护性和上皮完整性基因).
主要成果:
- 热应激降低了 brojlers 的生长性能,在接受阿斯塔丁治疗的群体中,这种下降较小.
- 阿斯塔丁治疗显著提高了细胞保护基因 (HSF2,SOD2,GPX3,TXN) 的调节.
- 表皮完整性基因 (LOX,CLDN1,MUC2) 也被阿斯塔克桑治疗上调.
结论:
- 阿斯塔丁可以增强肉大肠中对热应激的细胞反应.
- 抗氧化剂有效地减轻氧化损伤,并支持细胞保护能力.
- 阿斯塔克桑丁显示出通过基因表达调节改善 brojler 耐热压力的潜力.
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