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生命早期的补充增强了年轻大鼠的胃肠道免疫力和微生物群
Laura Sáez-Fuertes1,2, Garyfallia Kapravelou1, Blanca Grases-Pintó1,2
1Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain.
Foods (Basel, Switzerland)
|July 13, 2024
概括
母亲用Bifidobacterium breve M-16V和寡糖酸的同生菌补充剂改善了婴儿的肠道屏障功能和微生物群组成. 这一策略增强了胃肠道的成熟和殖民,改善了婴儿的肠道健康.
科学领域:
- * 儿科营养 儿童营养
- * 微生物组研究
- * 免疫学 免疫学
背景情况:
- * 免疫营养对婴儿免疫发育至关重要,利用母乳和饮食中的营养素.
- * 母亲的饮食显著影响婴儿的肠道微生物群和免疫系统成熟.
- *共生菌,结合益生菌和益生菌,为调节肠道健康提供了一个有希望的方法.
研究的目的:
- * 调查从怀孕到幼儿时期的母体共生补充剂 (Bifidobacterium breve M-16V,scGOS/lcFOS) 的影响.
- *评估对婴儿胃肠发育,免疫参数和肠道微生物群组成在粘膜和全身水平的影响.
主要方法:
- *孕妇在怀孕,哺乳期和幼儿早期期间补充Bifidobacterium breve M-16V和scGOS/lcFOS.
- * 评估婴儿生长,食物/水摄入量,小肠形态,基因表达 (FcRn,Blimp1,Zo1,Tlr9),免疫球蛋白A水平 (肠道和肠道),细菌丰富度和短链脂肪酸概况.
- *分析粘膜 (肠道,) 和全身免疫标记物以及微生物群组成.
主要成果:
- *同生菌补充促进了小肠的营养效应 (增加体重,长度,宽度) 和增强了屏障功能标记物 (Zo1, Tlr9基因表达).
- * 在眼中观察到的总细菌,Bifidobacterium和Ig涂层细菌的丰富性增加,随着短链脂肪酸生产的改变.
- * 没有对整体生长,食物/水摄入量,肠道IgA或全身免疫特征产生显著影响.
结论:
- * 母亲的协生补充剂是一种新的策略,可以提高婴儿的胃肠道屏障成熟和功能.
- *这种补充剂有助于健康的肠道微生物群殖民,有助于更强大的肠道微生物群.
- *这些发现支持协生菌作为改善婴儿肠道健康的手段,从生命早期开始.
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