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微波响应金属有机框架 (MOFs) 用于增强在体外控制释放多克索鲁比

Syeda Fiza Fatima¹, Rana Sabouni¹, Ghaleb Husseini¹

¹Department of Chemical and Biological Engineering, American University of Sharjah, Sharjah P.O.Box 26666, United Arab Emirates.

Nanomaterials (Basel, Switzerland)

|July 13, 2024

概括

微波辐射增强了多克索鲁比辛从金属有机框架 (MOF) 释放的作用,例如Fe-BTC和MIL-53 ((Al) 用于癌症治疗. 这种安全,热敏的方法对向药物输送和改善治疗结果有希望.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
药物输送系统药物输送系统

背景情况:

金属有机框架 (MOF) 具有较高的表面积,多孔性和稳定性,使其适用于药物输送.
像多克索鲁比 (DOX) 这样的化疗剂的控制释放对于有效的癌症治疗至关重要.
需要新的刺激反应系统来提高药物释放效率和向.

研究的目的:

研究微波 (MW) 辐射作为一种新的刺激,用于在体外从Fe-BTC和MIL-53 () MOFs中控制释放多克索鲁比辛 (DOX).
评估MW触发的DOX释放对增强癌症治疗的潜力.
评估MW辐射作为药物释放方式的安全性和有效性.

主要方法:

将DOX封装成Fe-BTC和MIL-53的MOF.
使用XRD,FTIR,TGA,BET,FE-SEM和EDX对MOF-DOX复合物的表征.
在不同pH值 (5.3和7.4) 的微波辐射下和没有辐射的情况下进行体外药物释放研究.
MTT测定用于评估细胞活力和MOF细胞毒性.

主要成果:

实现了高的药物加载效率:Fe-BTC高达67%,MIL-53{Al}高达40%.
微波辐射显著增强了DOX的释放:Fe-BTC在pH7.4时释放了54% (与没有MW的11%相比),在pH5.3时释放了40% (与没有MW的6%相比).
在MW照射下38分钟后,MIL-53 (((Al) 显示了pH依赖的释放,在pH 5.3下66%的释放.
MTT测定证实了MOF生物相容性和微波暴露对药物释放的安全性.

结论:

铁-BTC和MIL-53 (((Al) MOF是多克索鲁比传递的有效载体.
微波辐射作为一种强大,热敏的刺激,可以控制和增强这些MOF的药物释放.
这些发现支持基于MW触发的MOF药物递送系统在向癌症治疗中的潜力.

关键词:

MOF的特征表征是什么 MOF 的合成技术.MOFs 的使用情况.在药物输送中的MOFs.癌症癌症癌症癌症癌症德克索鲁比辛 (doxorubicin) 是一种药物.药物输送是药物输送的过程.金属有机的框架.微波炉可以使用微波炉.

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