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基于纳米库尔库明的无糖配方:发展和对糖尿病和氧化应激减轻的影响
Safa Ferradj1, Madiha Melha Yahoum2,3, Mounia Rebiha4
1Laboratory of Chemical Engineering, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria.
Nanomaterials (Basel, Switzerland)
|July 13, 2024
概括
这项研究开发了使用玉米粉和草粘液治疗氧化应激和糖尿病的新型纳米糖. 这些配方在老鼠中显示出增强的溶解,强大的抗氧化剂和显著的抗糖尿病活性.
科学领域:
- * 制药科学 制药科学
- * 材料科学 材料科学
- * 营养保健品 营养保健品
背景情况:
- *氧化应激和糖尿病是严重的健康问题.
- *黄素具有治疗潜力,但其生物可用性较差.
- * 需要新的输送系统来提高黄素的疗效.
研究的目的:
- * 开发和描述基于纳米的无糖糖.
- * 评估配方的稳定性,溶解性,抗氧化和抗糖尿病性质.
- * 探索纳米库尔库明在控制氧化应激和糖尿病方面的潜力.
主要方法:
- * 通过微化和封装在玉米粉和小松粘液中制备纳米.
- *使用Stevia rebaudiana*制造无糖糖.
- * 通过粒子大小分布和泽塔潜力进行稳定性评估.
- * 溶解速率研究.
- *使用DPPH测定进行抗氧化活性评估.
- * 在Wistar大鼠中评估抗糖尿病活性.
主要成果:
- * 实现了高封装效率 (75%的玉米粉,85%的草粘液).
- * 稳定配方,颗粒大小在117-119nm左右.
- * 与原始黄素相比,显著提高溶解速率 (67-70%的改善).
- *强大的抗氧化活性通过DPPH测定得到证实.
- * 糖尿病老鼠的禁食血糖水平显著降低 (392至187毫克/毫升).
- *肝脏外观的宏观改善表明氧化应激减少.
结论:
- * 无糖糖中的新型纳米素配方显示了改善的生物可用性和稳定性.
- * 这些配方具有显著的抗氧化和抗糖尿病潜力.
- *开发的纳米糖为氧化应激和糖尿病管理提供了有前途的治疗方法.
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