与代谢功能障碍相关的脂肪性肝病患者的休时间体育活动:全因死亡率研究
Ritanna Curci1, Caterina Bonfiglio2, Isabella Franco1
1Laboratory of Movement and Wellness, National Institute of Gastroenterology, IRCCS "S. de Bellis", Via Turi, 70013 Castellana Grotte, BA, Italy.
Journal of clinical medicine
|July 13, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了死亡风险,特别是在女性中. 休时间体力活动 (LTPA) 显著降低了这种风险,突出了其在管理MASLD和改善生存率方面的重要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球30%的成年人,与肥胖和心血管问题有关.
- 未经治疗的MASLD可能会发展为严重的肝病,强调需要进行干预.
- 身体活动和减肥等生活方式的改变对于减轻MASLD的严重程度和死亡风险至关重要.
研究的目的:
- 评估MASLD和休时间体育活动 (LTPA) 对死亡率的影响.
- 调查性别在MASLD-死亡率关系中的调解作用.
- 在意大利南部人口中分析这些因素.
主要方法:
- 基于人口的前性队列研究于1985年在意大利南部的Castellana Grotte开始.
- 包括30岁以上的参与者,收集有关健康,人类学,饮食和LTPA的数据.
- 通过当地市政记录追踪生命状况.
主要成果:
- 分析了1826名参与者 (39%患有MASLD);平均年龄为51.91岁,56.2%是男性.
- 与没有MASLD和高LTPA的患者相比,低LTPA的MASLD患者面临的死亡风险明显更高.
- 患有MASLD和低LTPA的个体存活到82岁的可能性降低了19%. 这种死亡风险在女性中较高.
结论:
- 存在MASLD显著增加了全因死亡风险,在女性中观察到的效果更为明显.
- LTPA是缓解MASLD相关死亡率的关键因素.
- 促进LTPA对于改善MASLD患者的治疗结果至关重要.
相关概念视频
Overview of Lipid Metabolism
1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
Exercise and Cardiovascular Response
775
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
775
Liver Physiology
502
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
502
Cholesterol: Significance and Regulation
533
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
533


