肺癌患者的静脉和动脉血栓栓塞:回顾性分析
Olga Morath1, Julia Hoffmann2, Kristina Schilling1
1Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747 Jena, Germany.
Journal of clinical medicine
|July 13, 2024
概括
免疫检查点抑制剂 (ICI) 不会增加肺癌患者的血栓事件. 腺癌和先前静脉血栓塞栓症 (VTE) 是关键的危险因素,而Khorana评分不是预测性的.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床研究 临床研究
背景情况:
- 肺癌患者有较高的静脉 (VTE) 和动脉 (ATE) 血栓栓塞的风险.
- 血栓形成的危险因素,特别是免疫检查点抑制剂 (ICI),需要进一步澄清.
研究的目的:
- 在接受基治疗的肺癌患者中比较VTE和ATE发病率与ICI.
- 为了验证在ICI治疗的背景下对VTE预测的Khorana风险评分.
主要方法:
- 对173名局部晚期或转移性肺癌患者 (2015-2021) 的回顾性分析.
- 不同治疗组 (基于的化疗,单独的ICI,组合治疗) 之间的血栓发生率的比较.
主要成果:
- 观察到VTE (17.9%) 和ATE (5.8%) 的高发病率.
- 腺癌组织学和先前的VTE病史是VTE的重要风险因素.
- 在基于的化疗和ICI治疗之间,血栓发生率没有显著差异 (p=0.19).
- 科拉纳风险评分未能准确预测VTE.
结论:
- 强度强化干扰治疗 (单独或联合) 似乎不会增加肺癌中血栓事件的风险.
- 腺癌和以前的静脉瘤是静脉瘤的强烈预测因素.
- 需要进行前性研究来评估替代性血栓形成风险评估得分.
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