埃皮鲁比辛和非肌肉侵入性膀癌治疗:一个系统性审查
Sever Chiujdea1, Matteo Ferro1,2, Mihai Dorin Vartolomei1,3
1Doctoral School, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Târgu Mureș, Romania.
Journal of clinical medicine
|July 13, 2024
概括
埃皮鲁比 (EPI) 的疗效与葛西他宾和米托米C在非肌肉侵入性膀癌 (NMIBC) 中具有相似的效果. 虽然BCG显示复发率较低,但EPI仍然是一个可行的选择,高温症显示出改善结果的希望.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉内化学疗法是中等风险的非肌肉侵入性膀癌 (NMIBC) 的标准.
- 埃皮鲁比 (EPI) 是一种广泛使用的药物,但其相对有效性和安全性尚未得到充分证实.
- 本研究解决了在NMIBC管理中对肠道EPI进行全面评估的需要.
研究的目的:
- 在NMIBC患者中系统地审查静脉注射Epirubicin (EPI) 的差异性疗效和安全性.
- 为了比较EPI的瘤结局 (复发,进展) 与其他辅助疗法,如米托米C (MMC),吉姆西塔 (GEM) 和Bacillus Calmette-Guérin (BCG).
- 评估EPI的安全性和高温对其疗效的影响.
主要方法:
- 在PubMed,科学网,clinicaltrials.gov和谷歌学者的系统文献搜索,截至2023年12月31日.
- 包括比较NMIBC与其他辅助疗法的TURBT后肠道EPI的研究.
- 对瘤结局,不良事件和与高温静脉EPI相关的结局的分析.
主要成果:
- 常见的EPI不良事件包括囊炎 (34%),失尿症和膀刺激.
- BCG显示复发率低于EPI;进展率相似.
- EPI的复发和进展率与MMC和GEM相似,其中一项研究显示GEM在高风险NMIBC中优越.
结论:
- 静脉内皮鲁比 (EPI) 的瘤性能与NMIBC的吉米他 (GEM) 和米托米C (MMC) 类似.
- Calmette-Guérin (BCG) 可能在降低复发率方面更优越.
- 像高温症这样的新型输送方法为提高静脉内疗法的疗效提供了有希望的途径.
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