阴道微生物组和妊娠并发症:一篇评论
Angeliki Gerede1, Konstantinos Nikolettos1, Eleftherios Vavoulidis2
1Unit of Maternal-Fetal-Medicine, Department of Obstetrics and Gynecology, Medical School, Democritus University of Thrake, GR-68100 Alexandroupolis, Greece.
Journal of clinical medicine
|July 13, 2024
概括
改变的阴道微生物组与妊娠并发症,如早产和产前有关. 一个健康的微生物群,特别是丰富的乳酸菌,可以提供对不良妊娠结果的保护.
科学领域:
- 生殖健康 生殖健康
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
背景情况:
- 母体粘膜表面的微生物组成与怀孕并发症有关.
- 了解阴道微生物组的作用对于管理妊娠健康至关重要.
研究的目的:
- 审查阴道微生物组变化与妊娠并发症风险之间的关联.
- 综合目前关于阴道失调和不良妊娠结果之间的联系的证据.
主要方法:
- 使用Medline和Scopus数据库进行了全面的文献审查.
- 搜索词包括"怀孕并发症"和"阴道*.
- 在查后,包括了44项研究.
主要成果:
- 阴道中微生物多样性的增加与早产,流产,孕前和其他并发症有关.
- 乳杆菌物种的减少与并发症有关,而增加的乳杆菌crispatus可能具有保护作用.
- 像Gardnerella和Prevotella这样的病原菌与增加的孕产妇发病率相关.
结论:
- 阴道微生物群异常似乎与不良怀孕事件有关.
- 需要进一步的高质量,同质的研究来证实这些关联.
- 准阴道微生物组可能为未来的妊娠并发症提供治疗策略.
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