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患有克罗恩氏病的成年人的特定口腔表现
Yavuz Cagir1, Muhammed Bahaddin Durak2, Cem Simsek2
1Department of Gastroenterology, Ankara Bilkent City Hospital, Bilkent, Ankara 06800, Turkey.
Journal of clinical medicine
|July 13, 2024
概括
克罗恩病 (CD) 中的特定口腔病变与活跃的疾病有关,并且对生物或免疫调节治疗有很好的反应. 通过牙医-胃肠科医生合作进行早期诊断是管理这些具有挑战性的口腔表现的关键.
科学领域:
- 胃肠道学和口腔医学
- 炎症性肠病 (IBD) 研究研究
- 临床牙科和患者管理
背景情况:
- 克罗恩病 (CD) 呈现出各种口腔表现,从非特异性病变到直接与肠道炎症相关的特定病变.
- 在CD患者中,某些口腔病变可能是微妙的,容易被忽视,并带来重大治疗挑战.
- 了解不同的口腔表现对于全面的CD患者护理至关重要.
研究的目的:
- 在克罗恩病患者中识别和描述特定的口腔病变.
- 为了比较口腔病变和没有口腔病变的CD患者之间的人口统计学,疾病相关和治疗变量.
- 评估特定的口腔病变与疾病活动,肠外干扰和治疗反应之间的关联.
主要方法:
- 回顾性单中心研究,包括成人CD患者随访.
- 对于特定的口腔病变的临床定义:植物性口腔炎,光炎,唇部胀,卵石,口腔面膜颗粒炎.
- 基于人口统计,疾病程度 (蒙特利尔分类),肠外表现和治疗方法 (生物药物,类固醇,手术) 的患者组 (没有口腔病变,非特异性,特异性) 的比较.
主要成果:
- 在676名CD患者中,有96人 (14.2%) 患有口腔病变;有8人 (1.2%) 患有特定病变 (面膜颗粒病变,布石,光,唇部胀).
- 特定的口腔病变在男性 (75%) 中更为常见,平均年龄为46.5岁,通常与结肠结肠病 (50%) 和中度至重度的疾病活动有关.
- 五名患有特定病变的患者通过生物疗法得到改善,两名患有免疫调节疗法,表明治疗反应.
结论:
- 克罗恩病中的特定口腔病变是活跃疾病的指标,并通过免疫调节剂或生物疗法证明了改善.
- 有效的管理需要胃肠科医生和牙医之间的密切合作,以便及时诊断和治疗口腔表现.
- 识别特定的口腔病变有助于评估疾病严重程度,并指导克罗恩病患者的治疗策略.
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