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放射性和[18F]-氧糖 (FDG) 在转移性分化甲状腺癌中的比较吸收模式

Devan Diwanji^1,2, Emmanuel Carrodeguas¹, Youngho Seo^1,3,4,5

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA.

Journal of clinical medicine

|July 13, 2024

概括

在转移性分化甲状腺癌 (DTC) 中,放射性 (RAI) 和氧糖 (FDG) 的吸收模式因分子状况和部位而异. 乳头组织学和BRAF V600E突变与肺转移中的FDG吸收增加有关.

科学领域:

在瘤学瘤学.
核医学就是核医学.
分子诊断学分子诊断学

背景情况:

转移性差异化甲状腺癌 (DTC) 是分子多样性的.
放射性 (RAI) 和氧糖 (FDG) 的吸收模式可能反映瘤脱差.
图像图案,分子状况和转移部位之间的相关性尚未得到充分理解.

研究的目的:

调查RAI和FDG吸收模式在转移性DTC中的关系.
确定这些模式是否与分子状态 (BRAF V600E突变) 和组织学 (乳头与卵泡) 相相关.
评估不同转移部位 (肺,淋巴结,骨头) 的吸收模式.

主要方法:

在一年内对46名转移性DTC患者进行了回顾性分析,并提供RAI全身扫描 (WBS) 和FDG-PET成像.
盲目放射科医生对额外甲状腺转移部位的和FDG吸收的解释.
根据BRAF V600E突变状态,组织学和综合基因型/组织学对病例进行分层分类.
统计分析使用麦克纳马尔的千平方测试.

主要成果:

肺转移表明FDG吸收 (84%) 显著高于RAI吸收 (52%).
与卵泡组织学和BRAF V600E-瘤相比,乳头组织学和BRAF V600E+瘤具有肺转移的FDG吸收率更高.
在患有乳头组织学或BRAF V600E+突变的患者中,RAI和FDG摄入量减少,特别是在肺转移中.
淋巴结吸收的低一致性在所有患者群体中是一致的.

结论:

转移性DTC中的FDG-PET和RAI吸收模式受分子特征和转移部位的影响.
乳头组织学和BRAF V600E突变与远程转移中FDG吸收增加有关,这表明潜在的脱差.
需要对更大的队列进行进一步的研究,以优化基于分子配置的DTC转移的监测和管理的成像策略.

关键词:

-131是一种.在这里,PET是PET.聚乙烯/聚乙烯/聚乙烯拉伊 (RAI) 是一个有差异化的甲状腺癌.定子发射断层扫描 (PET).甲状腺癌是一种癌症.

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