维生素D缺乏与糖尿病前期表型之间的关联:中国河南的一项基于人口的研究
Guojie Wang1, Shixian Feng2, Jiying Xu3
1Public Health School, Henan Medical College, Zhengzhou 451191, China.
Nutrients
|July 13, 2024
概括
维生素D缺乏 (VDD) 与男性的葡萄糖耐受性 (IGT) 有关,但与女性无关. 患有VDD的男性,特别是那些有糖尿病家族史的人,面临更高的IGT风险.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 关于维生素D缺乏 (VDD) 与糖尿病前期风险之间的联系存在不一致的证据.
- 糖尿病前期,以快食葡萄糖 (IFG) 或葡萄糖耐受性 (IGT) 损伤为特征,影响全球大量人口.
研究的目的:
- 调查河南人口中VDD和糖尿病前期 (IFG/IGT) 之间的性别相关性.
- 为了确定VDD是否是IFG或IGT的风险因素,考虑性别差异.
主要方法:
- 利用了河南慢性病和营养调查的数据.
- 采用复杂采样设计的多项物流回归模型来分析VDD和IFG/IGT之间的关联.
- 计算的赔率比率 (OR) 使用95%的置信区间 (95%CI).
主要成果:
- 在患有VDD (20.1%) 的男性中,与没有 (10.5%) 的男性相比,IGT的患病率显著更高.
- 在女性中,VDD和非VDD组之间没有发现IGT患病率的显著差异.
- 在两性中,VDD和非VDD组之间没有观察到IFG患病率的显著差异.
- 在男性中,VDD和IGT之间的关联在统计学上是显著的 (调整后OR:1.99;95%CI:1.24-3.19).
- 患有VDD和糖尿病家族病史的男性显示IGT的风险明显更高 (调整后OR:14.84;95%CI:4.14-53.20).
结论:
- 维生素D缺乏与男性葡萄糖耐受性受损的风险增加有关.
- 对于患有VDD和家族糖尿病史的男性来说,风险特别高.
- 这些发现强调了在葡萄糖代谢的背景下考虑维生素D状态的重要性,特别是在男性中.
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
521
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
521
Pedigree Analysis
84.2K
Overview
84.2K
Role of Skin in Vitamin D Synthesis
5.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Pathophysiology of Diabetes
917
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
917
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K


