探索血清B族维生素,同型半氨酸和精神障碍之间的关联:从孟德尔随机化中的见解
Yiming Hu1, Miao Yu1,2, Yaqiang Wang1,3
1National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Nutrients
|July 13, 2024
概括
这项研究表明,较高的维生素B12水平与焦虑和双相情感障碍的风险增加之间存在潜在的因果关系. 其他B族维生素和同类半氨酸没有与心理健康风险有显著的因果关系.
科学领域:
- 营养精神病学 营养精神病学
- 遗传流行病学遗传流行病学
- 心理健康研究 心理健康研究
背景情况:
- 维生素B和homocysteine (Hcy) 与心理健康有关,但与疾病的因果关系尚不清楚.
- 以前的研究表明关联,需要对因果关系进行强有力的调查.
研究的目的:
- 调查血清B族维生素 (叶酸,B6,B12) 和同类氨酸水平与五种常见精神障碍之间的潜在因果关系.
- 使用双样本的门德尔随机化 (MR) 方法进行因果推理.
主要方法:
- 采用孟德尔的随机化 (MR),使用50个单核酸多态 (SNP) 作为来自大型基因组广泛关联研究 (GWAS) 的仪器变量.
- 分析了叶酸,维生素B6,维生素B12和homocysteine的数据.
- 使用逆方差加权 (IVW),加权中位数 (WM) 和MR-Egger方法,以及对强度的灵敏度分析.
主要成果:
- 在血清维生素B12水平升高和焦虑障碍的风险增加之间发现了暗示性因果关系 (OR: 1.34,95%CI: 1.01-1.78).
- 血清维生素B12水平升高也表明与双相情感障碍有因果关系 (OR:1.85,95%CI:1.16-2.96).
- 血清叶酸,维生素B6和homocysteine水平似乎与研究精神障碍的风险无因果关联.
结论:
- 血清维生素B12水平升高可能与焦虑和双相情感障碍的风险增加有关.
- 叶酸,维生素B6和homocysteine不太可能对这些精神疾病的风险产生直接的因果关系.
- 由于潜在的水平质变性,需要在更大,更多样化的群体GWAS中进行进一步的验证.
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