从体内消化乳酪中获得的人类牛奶蛋白衍生生物活性对常见的新生儿病原体产生抗菌活性
Yang Lyu1, Bum Jin Kim2, Jagdish Suresh Patel3
1Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID 83844, USA.
Nutrients
|July 13, 2024
概括
人类牛奶对常见的婴儿死性肠球炎病原体表现出抗菌活性. 这些消化释放的可以在婴儿肠道中提供保护.
科学领域:
- 人母奶的成分 人母奶的成分
- 婴儿营养 婴儿营养
- 胃肠病学 胃肠病学
背景情况:
- 众所周知,母乳可以降低早产婴儿死性肠球炎 (NEC) 的风险.
- 新型乳腺癌影响着乳腺区域,在那里,消化的牛奶蛋白质产生了大量的.
- 这些可能具有生物活性特性,包括抗微生物和免疫调节功能.
研究的目的:
- 在体外消化之前和之后,对人乳粉中的特征.
- 通过计算预测这些的抗菌活性.
- 评估针对与NEC相关的细菌的选择性的抗菌疗效.
主要方法:
- 基于质谱的体组学被用于分析型.
- 实验室消化模型被用来模拟肠道条件.
- 基于序列的计算建模预测了抗菌活性.
- 合成的被测试对病原性细菌.
主要成果:
- 在未消化的和消化的胆乳中,类型有显著的差异.
- 消化的样本显示出更高的丰度.
- 鉴定和合成了四种特定的 (αS1-氨酸 [157-163],αS1-氨酸 [157-165],β-氨酸 [153-159],等离子素 [591-597]).
- 这四种都对Klebsiella aerogenes,Citrobacter freundii和Serratia marcescens表现出细菌静止活性,但不是对大肠杆菌.
结论:
- 人体牛奶的消化释放出具有抗菌性能的生物活性.
- 这些可以促进母乳对NEC的保护作用.
- 对这些的进一步研究可能会导致新的策略来预防和治疗NEC.
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