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高脂肪饮食增加了心肌炎症和心脏功能障碍在心律失常性心肌病症

Ann M Centner¹, Emily A Shiel¹, Waleed Farra¹

¹Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA.

|July 13, 2024

概括

高脂肪饮食 (HFD) 在遗传性心律失常性心肌病 (ACM) 鼠标模型中恶化了心脏功能障碍和重塑. 然而,饮食可能是ACM的可修改因素,并观察到潜在的保护作用.

科学领域:

心脏病学心脏病学
遗传学是一个遗传学.
营养科学营养科学

背景情况:

节律失常性心肌病 (ACM) 是一种遗传性心脏病,导致功能障碍,心律失常和炎症.
饮食等环境因素可能会影响ACM的进展,但它们的具体影响仍在调查中.

研究的目的:

研究高脂肪饮食 (HFD) 对心律失常性心肌病 (ACM) 发病和进展的影响.

主要方法:

一个强壮的ACM小鼠模型 (Desmoglein-2突变,Dsg2mut/mut) 被食HFD或对照食8周.
进行了心声学,心电学,以及对脂质负担,炎症标志物和纤维化的评估.

主要成果:

被HFD养的Dsg2mut/mut小鼠表现出恶化的心脏功能障碍,包括心律失常,左心室重塑和排气分数减少 (%LVEF).
血高密度脂蛋白 (HDL) 与%LVEF相关的升高,以及心肌腺基因 (AdipoQ,FGF1) 的增加,而没有增加心脏纤维化.
高血压疾病加剧了某些ACM表型,但并没有加剧疾病的所有方面.

结论:

饮食,特别是高脂肪饮食,可以显著影响ACM的进展,恶化心脏功能障碍和重塑.
增加的AdipoQ和HDL与%LVEF的正相关性表明潜在的保护机制需要进一步研究.
饮食修改代表了管理心律失常性心肌病的潜在治疗途径.

关键词:

德斯莫格莱因-2 的使用节律失常性心肌病变性心脏病变症有高脂肪的饮食.脂质脂质脂质是一种在心肌中,心肌.

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