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身体活动/运动对非传染性疾病中的miRNA表达和功能的影响 - - 一项系统性审查
Moomna Afzal1, Francesca Greco2, Federico Quinzi1
1Department of Clinical and Experimental Medicine, University Magna Grecia, 88100 Catanzaro, Italy.
International journal of molecular sciences
|July 13, 2024
概括
运动影响微RNAs (miRNAs),细胞通路的关键调节者,不同于非传染性疾病 (NCDs). 通过运动调节的特定miRNAs显示出作为NCDs治疗生物标志物的潜力.
科学领域:
- 分子生物学分子生物学
- 运动生理学 运动生理学
- 生物标志物 生物标志物
背景情况:
- 微RNAs (miRNAs) 是细胞和代谢途径的关键表观遗传调节者.
- 运动可以影响miRNA的表达,对非传染性疾病 (NCD) 有潜在的影响.
- miRNAs正在成为NCD预后和治疗的潜在治疗生物标志物.
研究的目的:
- 系统地审查运动诱导的miRNA表达变化与非传染性疾病之间的关联.
- 在患有非传染性疾病的人群中识别由身体活动调节的特定miRNAs.
- 探索运动调节miRNAs作为治疗点的潜力.
主要方法:
- 在PubMed,MEDLINE,Scopus和Web of Science (2023年6月) 的系统文献搜索.
- 遵守PRISMA指南的研究选择和数据提取.
- 使用ROB2和纽卡斯尔太华尺度进行偏差风险和质量评估.
主要成果:
- 在1047个初始记录中,有29项研究符合条件.
- 运动调节特定的miRNA,包括miR-146,miR-181,miR-133,miR-21和miRNA-1.
- 这些运动调节的miRNA与癌症,心血管疾病,COPD和T2DM等非传染性疾病的改善健康标志物有关.
结论:
- 运动诱导的miRNA调制与各种非传染性疾病的健康改善有关.
- 特定的miRNAs (例如,miR-146,miR-21) 显示出作为潜在的治疗点的希望.
- 对运动调节miRNA的进一步研究可能会导致新的NCD治疗策略.
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