高流动性组框-1对结肠癌粘膜免疫和上皮分化的影响
Takamitsu Sasaki1, Rina Fujiwara-Tani1, Yi Luo1
1Department of Molecular Pathology, Nara Medical University, 840 Shijo-Cho, Kashihara 634-8521, Nara, Japan.
International journal of molecular sciences
|July 13, 2024
概括
高流动性组盒-1 (HMGB1) 通过改变免疫细胞和减少上皮分化,促进性结肠炎 (UC) 中的结肠直肠癌 (CRC). HMGB1也会影响零星的CRC发育.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 粘膜免疫异常有助于性结肠炎 (UC) 和增加结直肠癌 (CRC) 的风险.
- 高流动性组盒-1 (HMGB1) 与结直肠癌发生有关,但其在与UC相关的CRC中的具体作用尚不清楚.
研究的目的:
- 调查HMGB1在UC相关的致癌和零星CRC中的作用.
- 阐明HMGB1影响粘膜免疫和上皮细胞行为的机制.
主要方法:
- 利用阿佐克西米和酸的牛硫酸模型在动物中诱导UC和CRC.
- 分析了粘膜免疫细胞群 (CD8+子集) 和上皮分化.
- 进行了体外研究,以评估HMGB1对细胞能量代谢的影响.
主要成果:
- 在UC和CRC模型中观察到粘膜HMGB1水平的增加.
- 观察到CD8+ T细胞种群的变化,包括耗尽和调节细胞的增加,以及原始和激活细胞的减少.
- 在CD8+细胞和肠道上皮细胞中,HMGB1诱导了对糖解的代谢重编程.
- HMGB1过度表达与人类UC发育不良,UC相关CRC和零星CRC组织中抑制的上皮分化相关.
结论:
- HMGB1是调节粘膜免疫的关键因素,并在UC相关和零星结直肠癌发生时促进上皮质脱差.
- 在慢性肠道炎症的背景下,HMGB1对免疫细胞功能和能量代谢的影响有助于癌症的发展.
更多相关视频
11:02Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.2K
06:31Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
Published on: June 2, 2023
977
相关概念视频
01:25Mucosal Barrier of the Stomach
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...