疑似子宫内膜异位症因植入失败而被医学抑制后的炎症变化:初步结果
Bruce A Lessey1, Allan Dong1, Jeffrey L Deaton1
1Department of OBGYN, Atrium Health Wake Forest Baptist, Winston-Salem, NC 27157, USA.
International journal of molecular sciences
|July 13, 2024
概括
无法解释的胚胎移植失败 (UEETF) 可能与子宫内膜异位症有关. 在胚胎移植之前使用GnRH抗体进行医学抑制,有望提高试管婴儿成功率.
科学领域:
- 生殖医学 生殖医学
- 遗传学 遗传学 是一个
- 内分泌学 在内分泌学.
背景情况:
- 无法解释的欧体胚胎移植失败 (UEETF) 占了30-50%的体外受精 (IVF) 在植入前遗传测试 (PGT-A) 之后失败的失败.
- 子宫内膜异位症被怀疑是UEETF的原因之一,诸如激素抑制或手术等治疗方法以前已经显示出好处.
研究的目的:
- 调查子宫内膜异位症在UEETF中的作用.
- 评估GnRH抗体治疗在改善欧普洛伊德胚胎移植成功方面的疗效.
主要方法:
- 在患有UEETF的女性中,对BCL6和SIRT1进行子宫内膜活检分析.
- 将PGT-A周期结果与GnRH激动剂治疗与对照结果进行比较.
- 试点随机对照试验比较elagolix (GnRH对抗剂) 与口服避孕药 (OCP) 在胚胎移植前进行抑制.
- 在治疗前后监测血液炎症和miRNA表达.
主要成果:
- 研究表明子宫内膜异位症和UEETF之间存在联系.
- 在胚胎移植之前使用GnRH抗剂治疗可能会提高成功率.
- 医学抑制解决了与UEETF相关的潜在炎症和表观遗传变化.
结论:
- 子宫内膜异位症与无法解释的胚胎移植失败有关.
- GnRH抗体治疗提供了一个潜在的策略,以提高受影响患者的试管婴儿结果.
- 需要对UEETF的炎症和表观遗传因素进行进一步的研究.
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