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约欣宾通过FOXO3a因子抑制PDGF诱导的血管光滑肌细胞增殖和迁移

Leejin Lim¹, Hyeonhwa Kim², Jihye Jeong²

¹Advanced Cancer Controlling Research Center, Chosun University, Gwangju 61452, Republic of Korea.

International journal of molecular sciences

|July 13, 2024

概括

约欣宾 (YHB) 通过调节FOXO3a和mTOR/p38/FAK通路来抑制血管光滑肌肉细胞的增殖和迁移. 这表明YHB是YHB.

科学领域:

心血管生物学心血管生物学
分子药理学分子药理学
细胞信号传输细胞信号传输

背景情况:

约欣宾 (YHB) 具有抗炎和抗癌性质.
YHB通过脂酶C-玛1通路抑制了血管光滑肌细胞 (VSMC) 的增殖和迁移.
尚不清楚YHB对VSMC行为的精确转录调节.

研究的目的:

阐明YHB在血小板衍生生生长因子 (PDGF) 诱导的VSMC中的转录调节机制.
研究YHB对细胞循环调节蛋白和关键信号通路的影响.
评估YHB在心血管疾病中的治疗潜力.

主要方法:

评估了YHB对细胞循环蛋白 (PCNA,环林,CDK4) 和转录因子FOXO3a的影响.
量化了YHB对p-38,mTOR和焦粘附激酶 (FAK) 酸化的影响.
研究了YHB对帕克西林表达和VSMC迁移/增殖的影响,包括与途径抑制剂的同时治疗.

主要成果:

通过调节FOXO3a,YHB降低了细胞循环蛋白的调节.
根据YHB的剂量,减少了p-38和mTOR酸化.
在Y397和Y925中,YHB显著降低了FAK酸化和帕克西林表达,在Y925中效果更大.
与mTOR或p38抑制剂的联合YHB治疗进一步降低了VSMC迁移和扩散.

结论:

YHB抑制了PDGF诱导的VSMC的扩散和迁移.
该机制涉及调节转录因子FOXO3a和mTOR/p38/FAK信号通路.
YHB显示出作为动脉样硬化和血管复缩的治疗剂的潜力.

关键词:

这就是FOXO3a.在mTOROR中使用mTOR.移民移民迁移迁移它们的扩散和扩散.血管光滑肌肉细胞血管光滑肌肉细胞约欣宾因 (Yohimbine) 是一种

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