在子宫内膜癌中细胞内加列-8和-9的表达
Susanne Beyer1, Maya Wehrmann1, Sarah Meister1
1Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377 Munich, Germany.
International journal of molecular sciences
|July 13, 2024
概括
在子宫内膜癌 (EC) 中,加勒-8和加勒-9的表达与患者的存活率相关. 细胞结合物加列-8是EC患者整体存活率和无进展存活率的积极预后因素.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 妇科瘤学 妇科瘤学
背景情况:
- 子宫内膜癌 (EC) 是一种流行的妇科恶性瘤,在晚期治疗选择有限.
- 质素参与各种细胞过程,它们的表达在几种瘤类型中升高.
- 目前,在欧洲共同体中调查素表达的大规模研究有限.
研究的目的:
- 为了研究 Galectin-8 (Gal-8) 和 Galectin-9 (Gal-9) 在子宫内膜癌组织中的表达.
- 为了将加勒素表达与组织病理学变量和患者生存结果相关联.
主要方法:
- 对225名子宫内膜癌患者的样本进行了免疫组织化学染色,使用Gal-8和Gal-9的抗体.
- 分析了Gal-8和Gal-9的表达水平和局部化 (细胞和核).
- 评估了加勒素表达和组织病理学变量,总生存期 (OS) 和无进展生存期 (PFS) 之间的统计相关性.
主要成果:
- -8和-9的细胞质表达与瘤分级和患者存活率有关.
- 细胞质Gal-8表达成为OS和PFS的显著积极预后因素.
- 核Gal-8表达与OS相关,而细胞质Gal-9与改善的OS相关.
结论:
- 加列-8和加列-9的表达,特别是在细胞质中,与子宫内膜癌的生存结果有关.
- 这些发现表明,加勒素是EC的潜在预后生物标志物.
- 需要进行进一步的研究,以阐明加勒素在EC进展中的作用背后的分子机制.
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