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石榴和提取物的抗菌潜力,单独或与抗生素对抗病原体的组合

Grace Farhat¹, Lewis Cheng¹, Emad A S Al-Dujaili²

¹Faculty of Health and Education, Manchester Metropolitan University, Manchester M15 6BG, UK.

International journal of molecular sciences

|July 13, 2024

概括

标准化石榴提取物 (PE) 显示出强烈的抗菌和抗真菌特性,优于一些抗生素对抗金黄色葡萄球菌. 然而,将PE或提取物 (LE) 与抗生素相结合并没有提高它们的疗效.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
自然产品化学化学

背景情况:

抗菌素耐药性是全球主要的健康威胁,推动了对替代疗法的研究.
富含多的植物提取物正在研究其抗菌潜力,以减少对抗生素的依赖.
之前的研究已经探索了各种植物提取物的抗真菌特性.

研究的目的:

评估标准化石榴提取物 (PE) 和提取物 (LE) 的抗菌和抗真菌活性.
为了比较PE和LE的抗菌疗效与针对特定细菌和酵母的常见抗生素.
评估PE或LE与抗生素对黄金葡萄球菌和大肠杆菌的联合作用.

主要方法:

标准化石榴提取物 (PE) 和提取物 (LE) 进行了对格兰氏阴性细菌,格兰氏阳性细菌和两种酵母菌种的测试.
使用抑制区 (ZOI) 试验评估了抗菌活性.
对PE或LE与抗生素 (Ciprofloxacin,Imipenem,Gentamicin,Ceftazidime) 的组合进行了针对金黄色葡萄球菌和大肠杆菌的评估.

主要成果:

PE显示出显著的杀菌和抗真菌作用,而LE显示出较少的抗菌 (主要是细菌静止) 和抗真菌活性.
PE的ZOI比西普罗夫洛克萨辛和Ceftazidime更高,并且与Gentamicin相比可以比较的ZOI对金黄色葡萄球菌.
结合PE或LE和抗生素,对抗菌活性产生中性或对抗性作用,对抗 Staphylococcus aureus 和 Escherichia coli.

结论:

石榴提取物 (PE) 具有显著的抗菌和抗真菌特性,表明作为替代治疗剂的潜力.
结合PE或LE与常规抗生素可能没有好处,可能会降低抗生素的疗效.
需要对最佳聚烯度进行进一步的研究,以探索协同效应和打击抗生素耐药性,并有可能用于未来的治疗应用.

关键词:

它具有抗微生物活性.抗生素耐药性抗生素耐药性抗氧化剂抗氧化剂是一种抗氧化剂.的提取物的提取物石榴的提取物石榴的提取物

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