Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Disorders of Erythrocytes01:27

Disorders of Erythrocytes

923
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
923
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

3.2K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.2K
Erythropoiesis01:14

Erythropoiesis

4.2K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
4.2K
Inflammation01:38

Inflammation

53.3K
Overview
53.3K
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

1.9K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
1.9K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

11.1K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England)·2026
Same author

Erythrocyte Fragility in Progressive Multiple Sclerosis.

European journal of neurology·2026
Same author

Alzheimer's disease diagnosis support for brain perfusion SPECT scans in a real-world clinical cohort.

Journal of Alzheimer's disease : JAD·2026
Same author

The international society of vascular behavioural and cognitive disorders: highlights from VasCog 2025 in the UK.

Cerebral circulation - cognition and behavior·2026
Same author

Real-World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria.

Annals of clinical and translational neurology·2026
Same author

Periodontitis and incident cognitive decline and dementia: A 15-year prospective cohort study of older men residing in Northern Ireland.

Journal of Alzheimer's disease : JAD·2025

相关实验视频

Updated: Jun 21, 2025

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

14.6K

轻度系统性炎症增加了红细胞脆弱性

Charlotte M Stuart1, Carmen Jacob1,2, Aravinthan Varatharaj1

  • 1Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.

International journal of molecular sciences
|July 13, 2024
PubMed
概括

轻微的系统性炎症会增加红细胞的脆弱性,可能导致血液溶解. 这项研究研究了小鼠和人类之间的联系,证实了炎症和红细胞脆弱性之间的联系.

关键词:
红细胞是红细胞.脆弱性是一种脆弱性.血液溶解 血液溶解这是一种炎症炎症炎症炎症.红细胞是血液中的红细胞.

更多相关视频

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

Published on: March 17, 2023

1.9K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.8K

相关实验视频

Last Updated: Jun 21, 2025

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

14.6K
Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

Published on: March 17, 2023

1.9K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.8K

科学领域:

  • 血液学 血液学 血液学
  • 免疫学 免疫学 免疫学
  • 身体生理学 身体生理学

背景情况:

  • 越来越多的证据表明,炎症会对红细胞 (红细胞) 的结构和功能产生负面影响.
  • 了解系统性炎症和红细胞脆弱性之间的关系对于理解血液溶解过程至关重要.

研究的目的:

  • 评估轻度系统性炎症对红细胞脆弱性的影响.
  • 调查炎症和红细胞脆弱性之间的因果关系.
  • 为了检查系统性炎症标志物与人体红细胞脆弱性之间的关联.

主要方法:

  • 在小鼠中测量了红细胞透脆弱性,这些小鼠通过活衰减细菌菌株诱导了低级系统性炎症.
  • 一项回顾性研究分析了英国生物库数据 (9,292名参与者),将血解标记与高灵敏度C反应蛋白相关联.
  • 一项前性研究测量了混合人群 (n=54) 中的红细胞对系统性炎症的透性脆弱性 (尿中新/肌素比率).

主要成果:

  • 面对细菌挑战的小鼠显示了红细胞透脆弱性的显著增加.
  • 人类研究表明,血液溶解和炎症标志物 (高灵敏度C反应蛋白) 之间存在关联.
  • 这项前性人类研究发现了系统性炎症和红细胞透脆弱性增加之间的相关性.

结论:

  • 轻微的全身炎症明显增加了红细胞的脆弱性.
  • 这种增加的脆弱性可能会导致红细胞的破坏 (血液溶解).
  • 需要进一步的研究来阐明分子机制和炎症性疾病的临床相关性.